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Magnetic CLEAR supports for solid-phase synthesis of peptides and small organic molecules

In English

Författare

Summary, in English

Paramagnetic versions of the CLEAR supports were prepared by entrapment of magnetite particles during suspension polymerization of allylamine, trimethylolpropane ethoxylate (14/3 EO/OH) triacrylate, and trimethylolpropane trimethacrylate. Swelling studies in a broad range of solvents showed comparable swelling of magnetic beads and regular CLEAR beads. The application of the magnetic beads as the support in solid-phase synthesis of peptides (Leu-enkephalinamide, substance P, acyl carrier protein (65-74) amide, and amyloid beta-protein (34-42) amide) and small organic affinity ligands based on the s-triazine scaffold was demonstrated. Adequate stability of the beads and retention of their magnetic properties were observed throughout the synthesis steps.

Publiceringsår

2007

Språk

Engelska

Sidor

129-141

Publikation/Tidskrift/Serie

International Journal of Peptide Research and Therapeutics

Volym

13

Issue

1-2

Dokumenttyp

Artikel i tidskrift

Förlag

Springer

Ämne

  • Pharmacology and Toxicology

Nyckelord

  • suspension polymerization
  • substance P
  • s-triazine scaffold
  • synthesis
  • solid-phase
  • resin
  • magnetite
  • magnetic support
  • Leu-enkephalin
  • CLEAR
  • acyl carrier protein (65-74)
  • amyloid beta-protein (34-42)

Status

Published

Forskningsgrupp

  • Nanomedicine and Biomaterials

ISBN/ISSN/Övrigt

  • ISSN: 1573-3904