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Prevalence of Helicobacter pylori vacA and cagA genotypes in Ethiopian dyspeptic patients

Författare

  • Daniel Asrat
  • Ingrid Nilsson
  • Yohannes Mengistu
  • Endale Kassa
  • Senait Ashenafi
  • Kiros Ayenew
  • Torkel Wadström
  • Waleed Abu Al-Soud

Summary, in English

A total of 300 gastric biopsy samples and 50 Helicobacter pylori isolates were collected from Ethiopian adult dyspeptic patients. The vacA and cagA genes were detected in 90 and 79% of biopsy specimens, respectively, and in 100 and 87% of clinical isolates, respectively. Both genes were detected in 84% of the gastric biopsy samples and in 87% of the clinical isolates. Among vacA genotypes, the s1/m1 genotype was the most common in gastric biopsy samples (48%). The vacA and cagA positive H. pylori strains were detected to a higher degree in patients with chronic active gastritis (71%) than patients with other histopathological findings (29%) (P < 0.05).

Publiceringsår

2004

Språk

Engelska

Sidor

2682-2684

Publikation/Tidskrift/Serie

Journal of Clinical Microbiology

Volym

42

Issue

6

Dokumenttyp

Artikel i tidskrift

Förlag

American Society for Microbiology

Ämne

  • Microbiology in the medical area

Status

Published

ISBN/ISSN/Övrigt

  • ISSN: 1098-660X