Crystallization and preliminary X-ray data analysis of beta-alanine synthase from Drosophila melanogaster
Författare
Summary, in English
beta-Alanine synthase catalyzes the last step in the reductive degradation pathway for uracil and thymine, which represents the main clearance route for the widely used anticancer drug 5-fluorouracil. Crystals of the recombinant enzyme from Drosophila melanogaster, which is closely related to the human enzyme, were obtained by the hanging-drop vapour-diffusion method. They diffracted to 3.3 angstrom at a synchrotron-radiation source, belong to space group C2 (unit-cell parameters a = 278.9, b = 95.0, c = 199.3 angstrom, beta = 125.8 degrees) and contain 8-10 molecules per asymmetric unit.
Avdelning/ar
Publiceringsår
2007
Språk
Engelska
Sidor
874-877
Publikation/Tidskrift/Serie
Acta Crystallographica. Section F: Structural Biology and Crystallization Communications
Volym
63
Dokumenttyp
Artikel i tidskrift
Förlag
Wiley-Blackwell
Ämne
- Biological Sciences
Status
Published
ISBN/ISSN/Övrigt
- ISSN: 2053-230X