Extinction of conditioned blink responses by cerebello-olivary pathway stimulation
Författare
Summary, in English
Learning of classically conditioned eyeblink responses depends on mechanisms within the cerebellum. It has been suggested that climbing fibres from the inferior olive transmit the unconditioned stimulus signal to the cerebellum. We have previously shown that the pathway from the deep cerebellar nuclei to the inferior olive inhibits olivary activity. It is known that repeated presentation of the conditioned stimulus on its own leads to extinction of the conditioned response. If the unconditioned stimulus signal is transmitted to the cerebellum via the inferior olive - climbing fibre system then stimulation of the nucleo-olivary pathway just before the unconditioned stimulus in a trained animal should lead to extinction. The results from this investigation confirm this.
Avdelning/ar
Publiceringsår
2007
Språk
Engelska
Sidor
1479-1482
Publikation/Tidskrift/Serie
NeuroReport
Volym
18
Issue
14
Dokumenttyp
Artikel i tidskrift
Förlag
Lippincott Williams & Wilkins
Ämne
- Neurosciences
Nyckelord
- extinction
- inferior olive
- unconditioned stimulus
- nucleo-olivary
- eyeblink conditioning
Status
Published
Forskningsgrupp
- Neural Basis of Sensorimotor Control
- Associative Learning
ISBN/ISSN/Övrigt
- ISSN: 1473-558X