Association between IgM against an aldehyde-modified peptide in apolipoprotein B-100 and progression of carotid disease

Summary, in English

Background and Purpose - Autoantibodies against antigens in oxidized low-density lipoprotein are common in people; experimental studies suggest that these immune responses have a functional role in the disease process. The aim of this study was to evaluate the relationship between the immune response against one defined oxidized low-density lipoprotein antigen, the aldehyde-modified peptide corresponding amino acids 3136 and 3155 (MDA-p210) in apolipoprotein (apo) B-100, and progression of carotid intima media thickness (IMT). Methods - IgM and IgG against MDA-p210 were determined by enzyme-linked immunosorbent assay at baseline and after 12 months of treatment with placebo, metoprolol, fluvastatin, or metoprolol/ fluvastatin in 751 individuals participating in the BCAPS. Carotid IMT was assessed by ultrasonography at baseline and after 18 and 36 months of treatment. Results - Antibody levels did not change in response to treatment, but high baseline MDA-p210 IgM levels were associated with a more rapid progression of carotid disease both at 18 ( r = 0.09, P < 0.05) and 36 months ( r = 0.12, P < 0.005). At 36 months, the difference in IMT progression rate per year between those with high MDA-p210 IgM levels and those with low was 0.011 mm ( 95% CI = 0.005 to 0.018 mm, P < 0.0001). Treatment with fluvastatin markedly decreased the progression of IMT among subjects with high but not with low MDA-p210 IgM levels. There was no association between MDA-p210 IgG and carotid IMT progression. Conclusions - IgM against the aldehyde-modified peptide corresponding amino acids 3136 and 3155 in apo B-100 is common in subjects with asymptomatic carotid disease, and high levels are associated with a more rapid progression of carotid IMT. The observation that the effect of fluvastatin was restricted to subjects with high MDA-p210 IgM levels may reflect the increased rate of disease progression in this group.

• Författare: Gunilla Nordin Fredrikson; Bo Hedblad; Göran Berglund; Ragnar Alm; Jan-Åke Nilsson; Alexandru Schiopu; Prediman K Shah; Jan Nilsson
• Avdelning/ar: Kardiovaskulär forskning - immunitet och ateroskleros; Kardiovaskulär forskning - epidemiologi; Internmedicin - epidemiologi; Ortopedi - klinisk och molekylär osteoporosforskning; Joint and Soft Tissue Unit
• Publiceringsår: 2007
• Språk: Engelska
• Sidor: 1495-1500
• Publikation/Tidskrift/Serie: Stroke: a journal of cerebral circulation
• Volym: 38
• Issue: 5
• Länkar: http://dx.doi.org/10.1161/STROKEAHA.106.474577
• Dokumenttyp: Artikel i tidskrift
• Förlag: American Heart Association
• Ämne: Neurology
• Nyckelord: carotid arteries; atherosclerosis; echocardiography; lipoproteins; immune system
• Status: Published
• Forskningsgrupp: Cardiovascular Research - Immunity and Atherosclerosis; Cardiovascular Research - Epidemiology; Internal Medicine - Epidemiology; Orthopedics - Clinical and Molecular Osteoporosis Research; Joint and Soft Tissue Unit
• ISBN/ISSN/Övrigt: ISSN: 1524-4628