Meny

Javascript is not activated in your browser. This website needs javascript activated to work properly.
Du är här

Loss of bHLH transcription factor E2A activity in primary effusion lymphoma confers resistance to apoptosis

Författare:
  • Andreas Lietz
  • Martin Janz
  • Mikael Sigvardsson
  • Franziska Jundt
  • Bernd Doerken
  • Stephan Mathas
Publiceringsår: 2007
Språk: Engelska
Sidor: 342-348
Publikation/Tidskrift/Serie: BRITISH JOURNAL OF HAEMATOLOGY
Volym: 137
Nummer: 4
Dokumenttyp: Artikel
Förlag: BLACKWELL PUBLISHING

Sammanfattning

Similar to classical Hodgkin lymphoma (HL) tumour cells, primary effusion lymphoma (PEL) originates from mature B cells but displays a non-B cell phenotype, the mechanisms and consequences of which are not yet understood. This study showed that PEL lacked DNA binding activity of the B cell-determining transcription factors E2A, EBF and Pax5. PEL overexpressed the E2A antagonists ABF-1 and Id2, which have been described to block the B-cell differentiation program in classical HL. However, in contrast to HL cells, B lineage-inappropriate genes were not similarly upregulated in PEL, and reconstitution of B cell-specific E2A homodimer activity in PEL induced apoptosis. These data demonstrate that lineage infidelity in PEL is not as pronounced as in HL, and that the loss of the B cell-specific transcription factor E2A in PEL is implicated in apoptosis protection.

Disputation

Nyckelord

  • Medicine and Health Sciences
  • E2A
  • lymphoma
  • primary effusion lymphoma
  • Hodgkin lymphoma

Övriga

Published
Yes
  • ISSN: 0007-1048

Box 117, 221 00 LUND
Telefon 046-222 00 00 (växel)
Telefax 046-222 47 20
lu [at] lu [dot] se

Fakturaadress: Box 188, 221 00 LUND
Organisationsnummer: 202100-3211
Om webbplatsen