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Loss of bHLH transcription factor E2A activity in primary effusion lymphoma confers resistance to apoptosis

Författare:
  • Andreas Lietz
  • Martin Janz
  • Mikael Sigvardsson
  • Franziska Jundt
  • Bernd Doerken
  • Stephan Mathas
Publiceringsår: 2007
Språk: Engelska
Sidor: 342-348
Publikation/Tidskrift/Serie: BRITISH JOURNAL OF HAEMATOLOGY
Volym: 137
Nummer: 4
Dokumenttyp: Artikel
Förlag: BLACKWELL PUBLISHING

Sammanfattning

Similar to classical Hodgkin lymphoma (HL) tumour cells, primary effusion lymphoma (PEL) originates from mature B cells but displays a non-B cell phenotype, the mechanisms and consequences of which are not yet understood. This study showed that PEL lacked DNA binding activity of the B cell-determining transcription factors E2A, EBF and Pax5. PEL overexpressed the E2A antagonists ABF-1 and Id2, which have been described to block the B-cell differentiation program in classical HL. However, in contrast to HL cells, B lineage-inappropriate genes were not similarly upregulated in PEL, and reconstitution of B cell-specific E2A homodimer activity in PEL induced apoptosis. These data demonstrate that lineage infidelity in PEL is not as pronounced as in HL, and that the loss of the B cell-specific transcription factor E2A in PEL is implicated in apoptosis protection.

Disputation

Nyckelord

  • Medicine and Health Sciences
  • E2A
  • lymphoma
  • primary effusion lymphoma
  • Hodgkin lymphoma

Övriga

Published
Yes
  • ISSN: 0007-1048

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