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Galectin-3 inhibits Schwann cell proliferation in cultured sciatic nerve

Författare:
Publiceringsår: 2007
Språk: Engelska
Sidor: 669-673
Publikation/Tidskrift/Serie: NeuroReport
Volym: 18
Nummer: 7
Dokumenttyp: Artikel
Förlag: Lippincott Williams & Wilkins

Sammanfattning

The production of galectin-3, a carbohydrate-binding mammalian lectin, is upregulated in Schwann cells after peripheral nerve injury in areas where Schwann cells proliferate. Here we tested if galectin-3 affected proliferation of Schwann cells in cultured sciatic nerve segments. Galectin-3 significantly decreased the number of bromodeoxyuridine-labelled Schwann cell nuclei. Neither lactose nor a synthetic inhibitor directed against the carbohydrate-binding region abolished the effects of galectin-3. In addition, a mutant galectin-3 unable to bind endogenous carbohydrates had similar effects as normal galectin-3. We conclude that galectin-3 reduces proliferation of Schwann cells in cultured sciatic nerve segments by a mechanism which is independent of its carbohydrate-binding moiety.

Disputation

Nyckelord

  • Medicine and Health Sciences
  • Wallerian degeneration
  • sciatic
  • Schwann cells
  • proliferation
  • in vitro
  • galectin-3
  • injury
  • nerve

Övriga

Published
Yes
  • ISSN: 0959-4965

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