RNA interference screening to detect targetable molecules in hematopoietic stem cells.

Summary, in English

The molecular principles regulating hematopoietic stem cells (HSCs) remain incompletely defined. In this review, we will discuss how RNA interference (RNAi) screening has emerged as a new and powerful tool to molecularly dissect various functional aspects of both normal and malignant HSCs, and how this may ultimately enable the discovery of novel therapeutic targets for clinical applications.

• Författare: Christine Karlsson; Justyna Rak; Jonas Larsson
• Avdelning/ar: Avdelningen för molekylärmedicin och genterapi; StemTherapy: National Initiative on Stem Cells for Regenerative Therapy
• Publiceringsår: 2014
• Språk: Engelska
• Sidor: 283-288
• Publikation/Tidskrift/Serie: Current Opinion in Hematology
• Volym: 21
• Issue: 4
• Länkar: http://www.ncbi.nlm.nih.gov/pubmed/24811164?dopt=Abstract; http://dx.doi.org/10.1097/MOH.0000000000000053
• Dokumenttyp: Artikel i tidskrift
• Förlag: Lippincott Williams & Wilkins
• Ämne: Hematology
• Status: Published
• ISBN/ISSN/Övrigt: ISSN: 1531-7048