Oral-based controlled release formulations using poly(acrylic acid) microgels.
Författare
Summary, in English
Aim: To investigate the release of hydrophobic and hydrophilic substances from tablets containing Pemulen and Carbopol as excipients. Method: The dissolution patterns of a hydrophobic (diazepam) and a hydrophilic active substance (midodrine-HCl) from different tablet formulations containing a nonmodified polyacrylic microgel (Carbopol 981 F) or a hydrophobically modified polyacrylic microgel (Pemulen(R)) have been studied. Possible differences in dissolution in phosphate buffer (pH 6.8) and in 0.1 M HCl between tablets produced using wet granulation and direct compression were also investigated. Results: Tablets produced by wet granulation had a greater effect on the release of active substance from the tablets. No major differences were observed in the release patterns of the hydrophilic substance midodrine-HCl from wet granulated tablets based on Carbopol and Pemulen. However, the release pattern of the more hydrophobic drug substance, diazepam, differed considerably between the two polymers. Wet granulation gave reproducible release patterns. The release patterns from the polymers differed considerably at pH 6.8 but were similar at low pH. Conclusions: The release of the diazepam from the hydrophobic polymer Pemulen was very slow, and the release was close to zero order.
Avdelning/ar
- Department of Food Technology, Engineering and Nutrition
- Avdelningen för livsmedel och läkemedel
Publiceringsår
2009
Språk
Engelska
Sidor
922-929
Publikation/Tidskrift/Serie
Drug Development and Industrial Pharmacy
Volym
35
Dokumenttyp
Artikel i tidskrift
Förlag
Marcel Dekker
Ämne
- Food Engineering
Status
Published
ISBN/ISSN/Övrigt
- ISSN: 0363-9045