High folate intake is associated with lower breast cancer incidence in postmenopausal women in the Malmö Diet and Cancer cohort
Författare
Summary, in English
BACKGROUND: Epidemiologic studies of associations between folate intake and breast cancer are inconclusive, but folate and other plant food nutrients appear protective in women at elevated risk.
OBJECTIVE: The objective was to examine the association between folate intake and the incidence of postmenopausal breast cancer.
DESIGN: This prospective study included all women aged >or=50 y (n = 11699) from the Malmö Diet and Cancer cohort. The mean follow-up time was 9.5 y. We used a modified diet-history method to collect nutrient intake data. At the end of follow-up, 392 incident invasive breast cancer cases were verified. We used proportional hazard regression to calculate hazard ratios (HRs).
RESULTS: Compared with the lowest quintile, the incidence of invasive breast cancer was reduced in the highest quintile of dietary folate intake (HR: 0.56; 95% CI: 0.35, 0.90; P for trend = 0.02); total folate intake, including supplements (HR: 0.56; 95% CI: 0.34, 0.91; P for trend = 0.006); and dietary folate equivalents (HR: 0.59; 95% CI: 0.36, 0.97; P for trend = 0.01).
CONCLUSION: A high folate intake was associated with a lower incidence of postmenopausal breast cancer in this cohort.
Avdelning/ar
Publiceringsår
2007-08
Språk
Engelska
Sidor
43-434
Publikation/Tidskrift/Serie
American Journal of Clinical Nutrition
Volym
86
Issue
2
Dokumenttyp
Artikel i tidskrift
Förlag
Oxford University Press
Ämne
- Nutrition and Dietetics
Nyckelord
- Aged
- Alcohol Drinking
- Breast Neoplasms
- Cohort Studies
- Female
- Folic Acid
- Humans
- Incidence
- Leisure Activities
- Middle Aged
- Neoplasm Invasiveness
- Postmenopause
- Proportional Hazards Models
- Smoking
- Socioeconomic Factors
- Sweden
Status
Published
Forskningsgrupp
- Diabetes - Cardiovascular Disease
- Nutrition Epidemiology
- Lund Melanoma Study Group
ISBN/ISSN/Övrigt
- ISSN: 0002-9165