Different outcome of allogeneic transplantation in myelofibrosis using conventional or reduced-intensity conditioning regimens
Författare
Summary, in English
Allogeneic haematopoietic stem cell transplantation remains the only curative treatment of myelofibrosis with myeloid metaplasia (MMM). Previous reports have indicated significant treatment-related mortality (TRM) for patients transplanted after myeloablative conditioning but superior survival has been reported after reduced-intensity conditioning (RIC). We report the results of a survey of all allogeneic transplantations for MMM performed in Sweden at six transplant units between 1982 and 2004. Twenty-seven patients were transplanted; 17 with a myeloablative conditioning regimen and 10 with RIC. The median age was 50 years (5-63 years) at transplantation. After a median follow up of 55 months, 20 patients are alive. TRM was 10% in the RIC group and 30% in the myeloablative group. There was no difference in survival for high or low-risk patients according to Cervantes score or between sibling and unrelated donor transplantations.
Avdelning/ar
Publiceringsår
2006
Språk
Engelska
Sidor
367-373
Publikation/Tidskrift/Serie
British Journal of Haematology
Volym
135
Issue
3
Länkar
Dokumenttyp
Artikel i tidskrift
Förlag
Wiley-Blackwell
Ämne
- Hematology
Nyckelord
- conditioning
- reduced intensity
- myelofibrosis
- allogeneic transplantation
- Cervantes score
Status
Published
ISBN/ISSN/Övrigt
- ISSN: 0007-1048