Superantigen activates the gp130 receptor on adipocytes resulting in altered adipocyte metabolism.
Författare
Summary, in English
The bacteria Staphylococcus aureus is part of the normal bacterial flora and produces a repertoire of enterotoxins which can cause food poisoning and toxic shock and might contribute to the pathogenesis of inflammatory diseases. These enterotoxins directly cross-link the T cell receptor with MHC class II, activating large amounts of T cells and are therefore called superantigens. It was recently discovered that the superantigen SEA binds to the cytokine receptor gp130. As obesity and type 2 diabetes are highly associated with inflammation of the adipose tissue and gp130 has been shown to play an important role in adipocytes, we wanted to investigate the effect of SEA on adipocyte signaling and function.
Avdelning/ar
Publiceringsår
2014
Språk
Engelska
Sidor
831-840
Publikation/Tidskrift/Serie
Metabolism, Clinical and Experimental
Volym
63
Issue
6
Länkar
Dokumenttyp
Artikel i tidskrift
Förlag
Elsevier
Ämne
- Cell and Molecular Biology
Status
Published
Forskningsgrupp
- Insulin Signal Transduction
- Medical Structural Biology
- Medical Protein Science
ISBN/ISSN/Övrigt
- ISSN: 1532-8600