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Single hollow fiber SLM extraction of polyamines followed by tosyl chloride derivatization and HPLC determination

In English

Författare

Summary, in English

Determination of polyamines in biological fluids possesses medical diagnostic relevance. Despite the vast panel of analytical methods developed for polyamines they are not applied in routine clinical usage, mainly due to the time and labor consuming sample preparation step and complicated derivatization. procedures. Thus, new simpler methods are needed. This paper describes a single hollow fiber SLM extraction method of polyarnines followed by simple pre-column derivatization with tosyl chloride and HPLC-UV analysis. The influence of different parameters such as the extraction time, organic phase composition, acceptor pH, donor pH, acceptor volume, donor volume and stirring speed on the transport parameters and enrichment was studied and discussed. The optimized method was applied to real matrices such as urine and plasma.

Publiceringsår

2008

Språk

Engelska

Sidor

184-193

Publikation/Tidskrift/Serie

Analytica Chimica Acta

Volym

606

Issue

2

Dokumenttyp

Artikel i tidskrift

Förlag

Elsevier

Ämne

  • Analytical Chemistry

Nyckelord

  • polyamines
  • extraction technique
  • hollow fiber membrane
  • supported liquid membrane

Status

Published

ISBN/ISSN/Övrigt

  • ISSN: 1873-4324