Webbläsaren som du använder stöds inte av denna webbplats. Alla versioner av Internet Explorer stöds inte längre, av oss eller Microsoft (läs mer här: * https://www.microsoft.com/en-us/microsoft-365/windows/end-of-ie-support).

Var god och använd en modern webbläsare för att ta del av denna webbplats, som t.ex. nyaste versioner av Edge, Chrome, Firefox eller Safari osv.

Transcription factor 7-like 2 (TCF7L2)

Författare

  • Struan F A Grant
  • Leif Groop

Summary, in English

In 2006 a genetic signal within the gene encoding transcription factor 7-like 2 (TCF7L2) was first reported to be associated with type 2 diabetes. Since then multiple genome-wide association studies have revealed this signal to be among the most strongest associations reported with this disease to date. Furthermore, multiple studies around the world have revealed the global relevance of this locus in intron 3 of the gene and have helped pinpoint, with relative confidence, the causal lesion at this locus. However, despite this association being beyond doubt, there is still a lack of consensus with respect to mechanisms of action and which tissue(s) it actually exerts its influence on the pathogenesis of type 2 diabetes.

Publiceringsår

2016-01-01

Språk

Engelska

Sidor

297-316

Publikation/Tidskrift/Serie

The Genetics of Type 2 Diabetes and Related Traits: Biology, Physiology and Translation

Dokumenttyp

Del av eller Kapitel i bok

Förlag

Springer International Publishing

Ämne

  • Medical Genetics

Status

Published

Forskningsgrupp

  • Genomics, Diabetes and Endocrinology

ISBN/ISSN/Övrigt

  • ISBN: 9783319015743
  • ISBN: 9783319015736