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Vascular endothelial growth factor-B-deficient mice display an atrial conduction defect

Författare

  • Karin Aase
  • Gabriel von Euler
  • Xuri Li
  • Annica Pontén
  • Peter Thoren
  • Renhai Cao
  • Yihai Cao
  • Birgitta Olofsson
  • Samuel Gebre-Medhin
  • Milos Pekny
  • Kari Alitalo
  • Christer Betsholtz
  • Ulf Eriksson

Summary, in English

BACKGROUND: Vascular endothelial growth factors (VEGFs) and their receptors are essential regulators of vasculogenesis and angiogenesis in both embryos and adults. One of the factors with a still unknown physiological function is VEGF-B, which is expressed in many tissues, including the heart. METHODS AND RESULTS: Mice carrying a targeted deletion in the VEGF-B gene were developed. In VEGF-B(-/-) animals, no gross abnormalities were observed in organs that normally show high expression of VEGF-B, such as the heart, muscle, and kidney. Analysis of heart function by ECG showed that adult VEGF-B(-/-) mice have an atrial conduction abnormality characterized by a prolonged PQ interval. VEGF- or basic fibroblast growth factor-induced corneal angiogenesis was similar in normal and VEGF-B(-/-) mice. CONCLUSIONS: VEGF-B seems to be required for normal heart function in adult animals but is not required for proper development of the cardiovascular system either during development or for angiogenesis in adults.

Publiceringsår

2001

Språk

Engelska

Sidor

358-358

Publikation/Tidskrift/Serie

Circulation

Volym

104

Issue

3

Dokumenttyp

Artikel i tidskrift

Förlag

Lippincott Williams & Wilkins

Ämne

  • Cardiac and Cardiovascular Systems

Nyckelord

  • electrocardiography
  • growth substances
  • angiogenesis
  • atrium
  • conduction

Status

Published

ISBN/ISSN/Övrigt

  • ISSN: 1524-4539