Short- and Long-Term Hormonal and Metabolic Consequences of Reversing Gastric Bypass to Normal Anatomy in a Type 2 Diabetes Patient.

Summary, in English

Gastric bypass (GBP) results in rapid type 2 diabetes (T2D) remission in most cases. Consequences of GBP reversal are unknown. A GBP-operated T2D patient was given mixed-meal tests before (MMTpre), 2 months (MMT2-M) and 12 months (MMT12-M) after GBP reversal. Glucose, hormones and metabolite profiles were assessed. MMT2-M displayed slightly lower glucose levels; MMT12-M displayed higher glucose and insulin levels, indicating deteriorating glycaemia. Homeostasis model assessment (HOMA)-β was higher at MMT2-M, but reduced at MMT12-M. Matsuda index revealed slightly reduced insulin sensitivity at MMT2-M, which deteriorated further at MMT12-M. Markers for metabolic stress and insulin resistance were elevated at MMT12-M. Gastric inhibitory polypeptide (GIP) levels were increased at MMT2-M and decreased at MMT12-M. Glucagon-like peptide-1 (GLP-1) decreased at MMT2-M and further decreased at MMT12-M. In conclusion, in this patient, GBP reversal provoked deteriorating glycaemia and long-term development of insulin resistance.

• Författare: Nils Wierup; Andreas Lindqvist; Peter Spégel; Leif Groop; Jan Hedenbro; Mikael Ekelund
• Avdelning/ar: Neuroendokrin cellbiologi; Diabetes - molekylär metabolism; Translationell Muskel Forskning; Kirurgi, Lund; EXODIAB: Excellence of Diabetes Research in Sweden
• Publiceringsår: 2015
• Språk: Engelska
• Sidor: 180-185
• Publikation/Tidskrift/Serie: Obesity Surgery
• Volym: 25
• Issue: 1
• Länkar: http://www.ncbi.nlm.nih.gov/pubmed/25330869?dopt=Abstract; http://dx.doi.org/10.1007/s11695-014-1459-8
• Dokumenttyp: Artikel i tidskrift
• Förlag: Springer
• Ämne: Surgery
• Status: Published
• Forskningsgrupp: Neuroendocrine Cell Biology; Diabetes - Molecular Metabolism; Genomics, Diabetes and Endocrinology
• ISBN/ISSN/Övrigt: ISSN: 1708-0428