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State-of-the-art MS technology applications in lung disease.

In English

Författare

  • Ákos Végvári
  • Balázs Döme

Summary, in English

Two frontline MS technologies, which have recently gained much attention, are discussed within the scope of this review. Besides a brief summary on the contemporary state of lung cancer and chronic obstructive pulmonary disease, the principles of multiple reaction monitoring and matrix assisted laser desorption ionization (MALDI) MS imaging are presented. A comprehensive overview of quantitative mass spectrometry applications is provided, covering multiple reaction monitoring assay developments for analysis of proteins (biomarkers) and low-molecular-weight compounds (drugs) with a special focus on the disease areas of lung cancer and chronic obstructive pulmonary disease. The MALDI-MS imaging applications are discussed similarly, providing references to studies conducted on lung tissues in order to localize drug compounds and protein biomarkers.

Publiceringsår

2011

Språk

Engelska

Sidor

2665-2677

Publikation/Tidskrift/Serie

Bioanalysis

Volym

3

Issue

23

Dokumenttyp

Artikel i tidskrift

Förlag

Future Science

Ämne

  • Pharmacology and Toxicology

Nyckelord

  • Lung cancer
  • Non-small cell lung cancer
  • Chronic obstructive pulmonary disease
  • Mass spectrometry
  • Multiple reaction monitoring
  • MALDI mass spectrometry imaging
  • Personalized medicine

Status

Published

ISBN/ISSN/Övrigt

  • ISSN: 1757-6180