Expression of fibromodulin in carotid atherosclerotic plaques is associated with diabetes and cerebrovascular events.
Författare
Summary, in English
The small leucine-rich proteoglycans fibromodulin and lumican are functionally related extracellular matrix proteins involved in the regulation of collagen fiber formation. Fibromodulin-deficient apolipoprotein E-null mice have decreased vascular retention of lipids and reduced development of atherosclerosis suggesting that fibromodulin may influence the disease process. The aim of the present study was to investigate if fibromodulin and lumican are expressed in human carotid plaques and to determine if their expression is associated with the occurrence of preoperative symptoms and with risk for postoperative cardiovascular events.
Avdelning/ar
Publiceringsår
2015
Språk
Engelska
Sidor
701-708
Publikation/Tidskrift/Serie
Atherosclerosis
Volym
241
Issue
2
Fulltext
Länkar
Dokumenttyp
Artikel i tidskrift
Förlag
Elsevier
Ämne
- Cardiac and Cardiovascular Systems
Status
Published
Forskningsgrupp
- Vessel Wall Biology
- Cardiovascular Research - Immunity and Atherosclerosis
- Cardiovascular Research - Translational Studies
ISBN/ISSN/Övrigt
- ISSN: 1879-1484