Galectin-3 inhibits Schwann cell proliferation in cultured sciatic nerve

Summary, in English

The production of galectin-3, a carbohydrate-binding mammalian lectin, is upregulated in Schwann cells after peripheral nerve injury in areas where Schwann cells proliferate. Here we tested if galectin-3 affected proliferation of Schwann cells in cultured sciatic nerve segments. Galectin-3 significantly decreased the number of bromodeoxyuridine-labelled Schwann cell nuclei. Neither lactose nor a synthetic inhibitor directed against the carbohydrate-binding region abolished the effects of galectin-3. In addition, a mutant galectin-3 unable to bind endogenous carbohydrates had similar effects as normal galectin-3. We conclude that galectin-3 reduces proliferation of Schwann cells in cultured sciatic nerve segments by a mechanism which is independent of its carbohydrate-binding moiety.

• Författare: Per Gustavsson; Cecilia Eriksson Linsmeier; Hakon Leffler; Martin Kanje
• Avdelning/ar: Funktionell zoologi; Biologiska institutionen; Neuronano Research Center (NRC); Avdelningen för mikrobiologi, immunologi och glykobiologi - MIG
• Publiceringsår: 2007
• Språk: Engelska
• Sidor: 669-673
• Publikation/Tidskrift/Serie: NeuroReport
• Volym: 18
• Issue: 7
• Länkar: http://www.neuroreport.com/pt/re/neuroreport/abstract.00001756-200705070-00010.htm
• Dokumenttyp: Artikel i tidskrift
• Förlag: Lippincott Williams & Wilkins
• Ämne: Neurosciences
• Nyckelord: Wallerian degeneration; sciatic; Schwann cells; proliferation; in vitro; galectin-3; injury; nerve
• Status: Published
• Forskningsgrupp: Neuronano Research Center (NRC)
• ISBN/ISSN/Övrigt: ISSN: 1473-558X