Increased Sensitivity to Broadly Neutralizing Antibodies of End-Stage Disease R5 HIV-1 Correlates with Evolution in Env Glycosylation and Charge.

Summary, in English

Induction of broadly neutralizing antibodies, such as the monoclonal antibodies IgGb12, 2F5 and 2G12, is the objective of most antibody-based HIV-1 vaccine undertakings. However, despite the relative conserved nature of epitopes targeted by these antibodies, mechanisms underlying the sensitivity of circulating HIV-1 variants to broadly neutralizing antibodies are not fully understood. Here we have studied sensitivity to broadly neutralizing antibodies of HIV-1 variants that emerge during disease progression in relation to molecular alterations in the viral envelope glycoproteins (Env), using a panel of primary R5 HIV-1 isolates sequentially obtained before and after AIDS onset.

• Författare: Marie Borggren; Johanna Repits; Jasminka Sterjovski; Hannes Uchtenhagen; Melissa J Churchill; Anders Karlsson; Jan Albert; Adnane Achour; Paul R Gorry; Eva Maria Fenyö; Marianne Jansson
• Avdelning/ar: Avdelningen för medicinsk mikrobiologi; HIV-1 och HIV-2 värd interaktioner
• Publiceringsår: 2011
• Språk: Engelska
• Publikation/Tidskrift/Serie: PLoS ONE
• Volym: 6
• Issue: 6
• Fulltext: - 425 kB; Download statistics
• Länkar: http://www.ncbi.nlm.nih.gov/pubmed/21698221?dopt=Abstract; http://dx.doi.org/10.1371/journal.pone.0020135
• Dokumenttyp: Artikel i tidskrift
• Förlag: Public Library of Science (PLoS)
• Ämne: Microbiology in the medical area
• Status: Published
• Forskningsgrupp: HIV-1 and HIV-2 host interactions
• ISBN/ISSN/Övrigt: ISSN: 1932-6203