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The structure of the semenogelin gene locus--nucleotide sequence of the intergenic and the flanking DNA

Författare

Summary, in English

The sequence of 15.7 kb from the human semenogelin gene locus has been determined. Together with previously published sequences, this gives the structure of a 28-kb region encompassing the two semenogelin genes. The two transcription units are separated by 11616 bp intergenic DNA comprising more than 40% repetitive DNA sequences, predominantly located to a 4-kb block of L1 and Alu repeats. Two more blocks of L1 sequences are present in the DNA flanking the genes, so that approximately 20% of the completed sequence consists of long interspersed repeated sequences, so called LINES. A comparison of the SgI gene and the SgII gene suggests that they evolved by the duplication of an approximately 8 kb DNA segment about 61 million years ago, probably by a mechanism involving recombination between L1 elements.

Publiceringsår

1996

Språk

Engelska

Sidor

70-466

Publikation/Tidskrift/Serie

Eur J Biochem

Volym

235

Issue

3

Dokumenttyp

Artikel i tidskrift

Förlag

Wiley-Blackwell

Ämne

  • Medicinal Chemistry

Nyckelord

  • Repetitive Sequences
  • Multigene Family
  • Molecular Sequence Data
  • Humans
  • Gonadal Steroid Hormones/*genetics
  • Dna
  • Molecular
  • Cloning
  • Base Sequence
  • Chromosome Mapping
  • Nucleic Acid
  • Non-U.S. Gov't
  • Research Support
  • *Seminal Vesicle Secretory Proteins
  • Sequence Homology

Status

Published

Forskningsgrupp

  • Clinical Chemistry, Malmö