Early diagnostic value of Bcl-3 localization in colorectal cancer.

Summary, in English

B-cell leukemia 3 (Bcl-3) is a member of the inhibitor of κB family, which regulates a wide range of biological processes by functioning as a transcriptional activator or as a repressor of target genes. Elevated expression, sustained nuclear accumulation, and uncontrolled activation of Bcl-3 causes increased cellular proliferation or survival, dependent on the tissue and type of stimuli.

• Författare: Karunakar Saamarthy; Sofie Björner; Martin Johansson; Göran Landberg; Ramin Massoumi; Karin Jirström; Katarzyna Masoumi
• Avdelning/ar: Avdelningen för translationell cancerforskning; Patologi, Malmö; Klinisk patologi, Malmö; BioCARE: Biomarkers in Cancer Medicine improving Health Care, Education and Innovation; Tumörmikromiljö
• Publiceringsår: 2015
• Språk: Engelska
• Publikation/Tidskrift/Serie: BMC Cancer
• Volym: 15
• Issue: 1
• Fulltext: - 3 MB; Download statistics
• Länkar: http://www.ncbi.nlm.nih.gov/pubmed/25929479?dopt=Abstract; http://dx.doi.org/10.1186/s12885-015-1342-6
• Dokumenttyp: Artikel i tidskrift
• Förlag: BioMed Central (BMC)
• Ämne: Cancer and Oncology
• Status: Published
• Forskningsgrupp: Pathology, Malmö; Clinical pathology, Malmö
• ISBN/ISSN/Övrigt: ISSN: 1471-2407