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Construction of polyamine-modified uridine and adenosine derivatives-evaluation of DNA binding capacity and cytotoxicity in vitro

Författare:
Publiceringsår: 2007
Språk: Engelska
Sidor: 7426-7433
Publikation/Tidskrift/Serie: Bioorganic & medicinal chemistry
Volym: 15
Nummer: 23
Dokumenttyp: Artikel
Förlag: Elsevier

Sammanfattning

We here report the synthesis of the two polyamine-based nucleoside derivatives 5-{[bis-(3-aminopropyl)amino]acetamido-1-propynyl}uridine and 2-{[bis-(3-aminopropyl)amino]-acetamido-1-propynyl}adenosine. The various polyamine derivatives have been used in thermal melting analysis using DNA from herring testes, and in cellular studies using four different cell lines. The compounds were all found to be non-toxic, thus holding good promise for future use as siRNA building blocks.

Disputation

Nyckelord

  • Chemistry
  • Modified nucleoside
  • Adenosine
  • Uridine
  • Polyamine derivatives

Övriga

Published
Yes
  • ISSN: 0968-0896
  • ISSN: 1464-3391

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