Expression of fibromodulin in carotid atherosclerotic plaques is associated with diabetes and cerebrovascular events.

Summary, in English

The small leucine-rich proteoglycans fibromodulin and lumican are functionally related extracellular matrix proteins involved in the regulation of collagen fiber formation. Fibromodulin-deficient apolipoprotein E-null mice have decreased vascular retention of lipids and reduced development of atherosclerosis suggesting that fibromodulin may influence the disease process. The aim of the present study was to investigate if fibromodulin and lumican are expressed in human carotid plaques and to determine if their expression is associated with the occurrence of preoperative symptoms and with risk for postoperative cardiovascular events.

• Författare: Annelie Shami; Christoffer Tengryd; Giuseppe Asciutto; Eva Bengtsson; Jan Nilsson; Anna Hultgårdh; Isabel Goncalves
• Avdelning/ar: EXODIAB: Excellence of Diabetes Research in Sweden; EpiHealth: Epidemiology for Health; Kärlväggsbiologi; Kardiovaskulär forskning - immunitet och ateroskleros; Kardiovaskulär forskning - translationella studier
• Publiceringsår: 2015
• Språk: Engelska
• Sidor: 701-708
• Publikation/Tidskrift/Serie: Atherosclerosis
• Volym: 241
• Issue: 2
• Fulltext: - 6 MB; Download statistics
• Länkar: http://www.ncbi.nlm.nih.gov/pubmed/26125412?dopt=Abstract; http://dx.doi.org/10.1016/j.atherosclerosis.2015.06.023
• Dokumenttyp: Artikel i tidskrift
• Förlag: Elsevier
• Ämne: Cardiac and Cardiovascular Systems
• Status: Published
• Forskningsgrupp: Vessel Wall Biology; Cardiovascular Research - Immunity and Atherosclerosis; Cardiovascular Research - Translational Studies
• ISBN/ISSN/Övrigt: ISSN: 1879-1484