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Clinical system for non-invasive in situ monitoring of gases in the human paranasal sinuses

In English

Författare

Summary, in English

We present a portable system for non-invasive, simultaneous sensing of molecular oxygen (O-2) and water vapor (H2O) in the human paranasal cavities. The system is based on high-resolution tunable diode laser spectroscopy (TDLAS) and digital wavelength modulation spectroscopy (dWMS). Since optical interference and non-ideal tuning of the diode lasers render signal processing complex, we focus on Fourier analysis of dWMS signals and procedures for removal of background signals. Clinical data are presented, and exhibit a significant improvement in signal-to-noise with respect to earlier work. The in situ detection limit, in terms of absorption fraction, is about 5 x 10(-5) for oxygen and 5 x 10(-4) for water vapor, but varies between patients due to differences in light attenuation. In addition, we discuss the use of water vapor as a reference in quantification of in situ oxygen concentration in detail. In particular, light propagation aspects are investigated by employing photon time-of-flight spectroscopy. (C) 2009 Optical Society of America

Publiceringsår

2009

Språk

Engelska

Sidor

10849-10863

Publikation/Tidskrift/Serie

Optics Express

Volym

17

Issue

13

Dokumenttyp

Artikel i tidskrift

Förlag

Optical Society of America

Ämne

  • Atom and Molecular Physics and Optics

Status

Published

Forskningsgrupp

  • Biophotonics

ISBN/ISSN/Övrigt

  • ISSN: 1094-4087