Potential Biomarkers for Radiation-Induced Renal Toxicity following 177Lu-Octreotate Administration in Mice.

Summary, in English

C57BL/6N mice were i.v. injected with 0, 30, 60, 90, 120, or 150 MBq 177Lu-octreotate (0, 16, 29, 40, 48, and 54 Gy to the kidneys). At 4, 8, and 12 months after administration, radiation-induced effects were evaluated in relation to (a) global transcriptional variations in kidney tissues, (b) morphological changes in the kidneys, (c) changes in white and red blood cell count as well as blood levels of urea, and (d) changes in renal function using 99mTc-DTPA/99mTc-DMSA scintigraphy.

• Författare: Emil Schüler; Maria Larsson; Toshima Z Parris; Martin Johansson; Khalil Helou; Eva Forssell-Aronsson
• Avdelning/ar: Klinisk patologi, Malmö; BioCARE: Biomarkers in Cancer Medicine improving Health Care, Education and Innovation
• Publiceringsår: 2015
• Språk: Engelska
• Publikation/Tidskrift/Serie: PLoS ONE
• Volym: 10
• Issue: 8
• Fulltext: - 3 MB; Download statistics
• Länkar: http://www.ncbi.nlm.nih.gov/pubmed/26287527?dopt=Abstract; http://dx.doi.org/10.1371/journal.pone.0136204
• Dokumenttyp: Artikel i tidskrift
• Förlag: Public Library of Science (PLoS)
• Ämne: Radiology, Nuclear Medicine and Medical Imaging
• Status: Published
• Forskningsgrupp: Clinical pathology, Malmö
• ISBN/ISSN/Övrigt: ISSN: 1932-6203