Convergence in probiotic Lactobacillus gut-adaptive responses in humans and mice
Författare
Summary, in English
Probiotic bacteria provide unique opportunities to study the global responses and molecular mechanisms underlying the effects of gut-associated microorganisms in the human digestive tract. In this study, we show by comparative transcriptome analysis using DNA microarrays that the established probiotic Lactobacillus plantarum 299v specifically adapts its metabolic capacity in the human intestine for carbohydrate acquisition and expression of exopolysaccharide and protein-aceous cell surface compounds. This report constitutes the first application of global gene expression profiling of a commensal microorganism in the human gut. A core L. plantarum transcriptome expressed in the mammalian intestine was also determined through comparisons of L. plantarum 299v activities in humans to those found for L. plantarum WCFS1 in germ-free mice. These results identify the niche-specific adaptations of a dietary microorganism to the intestinal ecosystem and provide novel targets for molecular analysis of microbial-host interactions which affect human health. The ISME Journal (2010) 4, 1481-1484; doi: 10.1038/ismej.2010.61; published online 27 May 2010
Avdelning/ar
Publiceringsår
2010
Språk
Engelska
Sidor
1481-1484
Publikation/Tidskrift/Serie
The Isme Journal
Volym
4
Issue
11
Dokumenttyp
Artikel i tidskrift
Förlag
Nature Publishing Group
Ämne
- Surgery
Nyckelord
- intestine
- transcript profiling
- germ-free mice
- gut microbiota
- diet
- in vivo-inducible genes
Status
Published
Forskningsgrupp
- Surgery
ISBN/ISSN/Övrigt
- ISSN: 1751-7362