The leukotriene receptor CysLT1 and 5-lipoxygenase are upregulated in colon cancer.
Författare
Summary, in English
The metabolites of arachidonic acid are well connected to pathological situations such as inflammation, cancer and asthmA. Sheng et al. [7] found that COX-2 is upregulated in colon cancer tissue and tumor cell lines indicating that COX-2 is involved in colon cancer. This is supported by studies showing that patients treated with nonsteroidal anti-inflammatory drugs, inhibitors of COX-2, exhibit a lower frequency of colon cancer [8]. When the non-transformed intestinal epithelial cell line, Int 407 was stimulated with LTD4 or LTB4 we observed an accumulation of COX-2 in membrane fractions as well as an increased production of prostaglandin E2 [5]. Treatment of these cells with the COX-2 inhibitor NS-398 caused apoptosis and this effect could be prevented by LTD4 [5] or LTB4 [4]. Similar results were obtained when cell viability with LTD4 or LTB4 in the presence or absence of NS-398 was assayed [4,5]. The results demonstrate that these leukotrienes can suppress the NS-398 induced apoptosis in intestinal cells.
Publiceringsår
2003
Språk
Engelska
Sidor
201-204
Publikation/Tidskrift/Serie
Advances in Experimental Medicine and Biology
Volym
525
Dokumenttyp
Del av eller Kapitel i bok
Förlag
Springer
Ämne
- Cancer and Oncology
Status
Published
Forskningsgrupp
- Experimental Pathology, Malmö
ISBN/ISSN/Övrigt
- ISSN: 0065-2598
- ISBN: 978-0-306-47763-8