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Of genes and phenotypes: the immunological and molecular spectrum of combined immune deficiency. Defects of the gamma(c)-JAK3 signaling pathway as a model

Författare

  • LD Notarangelo
  • S Giliani
  • C Mazza
  • P Mella
  • G Savoldi
  • C Rodriguez-Perez
  • E Mazzolari
  • M Fiorini
  • M Duse
  • A Plebani
  • AG Ugazio
  • Mauno Vihinen
  • F Candotti
  • RF Schumacher

Summary, in English

Cytokines play a major role in lymphoid development. Defects of the common gamma chain (gamma (c)) or of the JAK3 protein in humans have been shown to result in a severe combined immune deficiency (SCID), with a profound defect in T and natural killer (NK)-cell development, whereas B-cell generation is apparently unaffected (T-B+NK- SCID). While extensive molecular and biochemical analysis of these patients has been instrumental in understanding better the biological properties of the gamma (c) and JAK3 protein, an unexpected phenotypic heterogeneity of gamma (c) and JAK3 deficiency has emerged, indicating the need for appropriate and extensive investigations even in patients with atypical presentations. At the same time, characterization of the defects has been instrumental in the development of never therapeutic approaches, from in utero hematopoietic stem cell transplantation to gene therapy.

Publiceringsår

2000

Språk

Engelska

Sidor

39-48

Publikation/Tidskrift/Serie

Immunological Reviews

Volym

178

Dokumenttyp

Artikel i tidskrift

Förlag

Wiley-Blackwell

Ämne

  • Immunology in the medical area

Status

Published

ISBN/ISSN/Övrigt

  • ISSN: 1600-065X