Laser-induced Fluorescence In Malignant and Normal Tissue of Rats Injected With Benzoporphyrin Derivative

Summary, in English

Laser-induced fluorescence was used to characterize the localization of intravenously administered benzoporphyrin derivative-monoacid (BPD-MA) 3 h postinjection in different rat tissue types, including an induced experimental malignant tumor. A comparison of the fluorescence properties and the demarcation potential between the newer sensitizer BPD-MA and four other substances, hematoporphyrin (HP), polyhematoporphyrin ester (PHE), tetrasulfonated phthalocyanine (TSPc) and the commercially available Photofrin earlier investigated, is included. The fluorescence light was induced with a nitrogen laser, emitting at 337 nm. The fluorescence spectrum in the region 380-750 nm was analyzed by a polychromator equipped with a diode array detector. The demarcation potential between tumor and surrounding tissue in terms of fluorescence signal for the tumor model used was 2:1 for BPD-MA. In comparison with the other drugs, HP shows about the same demarcation potential, whereas Photofrin and PHE exhibit about 3 times better and TSPc about 1.5 times better demarcation. By also employing the endogenous tissue fluorescence signature the contrast was enhanced by a factor of about 2 for each of the five drugs.

• Författare: Stefan Andersson-Engels; J Ankerst; Jonas Johansson; Katarina Svanberg; Sune Svanberg
• Avdelning/ar: Atomfysik; Medicin/akutsjukvård, Lund
• Publiceringsår: 1993
• Språk: Engelska
• Sidor: 978-983
• Publikation/Tidskrift/Serie: Photochemistry and Photobiology
• Volym: 57
• Issue: 6
• Fulltext: - 615 kB; Download statistics
• Länkar: http://dx.doi.org/10.1111/j.1751-1097.1993.tb02958.x
• Dokumenttyp: Artikel i tidskrift
• Förlag: American Society for Photobiology
• Ämne: Atom and Molecular Physics and Optics
• Status: Published
• ISBN/ISSN/Övrigt: ISSN: 0031-8655