Osteopontin binds and modulate functions of eosinophil-recruiting chemokines.
Författare
Summary, in English
Allergic asthma is characterized by eosinophilic inflammation and airway obstruction. There is also an increased risk of pulmonary infection caused by Streptococcus pneumoniae, in particular during severe asthma where high levels of the glycoprotein, osteopontin (OPN) are present in the airways. Eosinophils can be recruited by chemokines activating the receptor CCR3 including eotaxin-1/CCL11, eotaxin-2/CCL24, eotaxin-3/CCL26, RANTES/CCL5, and MEC/CCL28. In addition to inducing chemotaxis, several of these molecules have defensin-like antibacterial properties. This study set out to elucidate the functional consequences of OPN-binding to eosinophil-recruiting chemokines.
Publiceringsår
2016
Språk
Engelska
Sidor
58-67
Publikation/Tidskrift/Serie
Allergy
Volym
71
Issue
1
Länkar
Dokumenttyp
Artikel i tidskrift
Förlag
Wiley-Blackwell
Ämne
- Respiratory Medicine and Allergy
Status
Published
Forskningsgrupp
- Airway Inflammation and Immunology
ISBN/ISSN/Övrigt
- ISSN: 1398-9995