iNOS affects matrix production in distal lung fibroblasts from patients with mild asthma.

Summary, in English

A high level of exhaled nitric oxide (NO) is a marker for inflammation in the airways of asthmatic subjects. However, little is known about how NO and inducible nitric oxides synthase (iNOS) activity may affect remodelling in the distal lung. We hypothesized that there is a link between iNOS and ongoing remodelling processes in the distal lung of mild asthmatics.

• Författare: Anna-Karin Larsson Callerfelt; Maria Weitoft; Kristian Nihlberg; Leif Bjermer; Gunilla Westergren-Thorsson; Ellen Tufvesson
• Avdelning/ar: EpiHealth: Epidemiology for Health; Lungbiologi; Lungmedicin, allergologi och palliativ medicin; Lungfysiologi och biomarkörer
• Publiceringsår: 2015
• Språk: Engelska
• Sidor: 64-71
• Publikation/Tidskrift/Serie: Pulmonary Pharmacology & Therapeutics
• Volym: 34
• Issue: sep 9
• Fulltext: - 475 kB; Download statistics
• Länkar: http://www.ncbi.nlm.nih.gov/pubmed/26362859?dopt=Abstract; http://dx.doi.org/10.1016/j.pupt.2015.09.003
• Dokumenttyp: Artikel i tidskrift
• Förlag: Elsevier
• Ämne: Respiratory Medicine and Allergy
• Status: Published
• Forskningsgrupp: Lung Biology; Lung physiology and biomarkers
• ISBN/ISSN/Övrigt: ISSN: 1522-9629