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Selection Shapes Transcriptional Logic and Regulatory Specialization in Genetic Networks.

In English

Författare

Summary, in English

Living organisms need to regulate their gene expression in response to environmental signals and internal cues. This is a computational task where genes act as logic gates that connect to form transcriptional networks, which are shaped at all scales by evolution. Large-scale mutations such as gene duplications and deletions add and remove network components, whereas smaller mutations alter the connections between them. Selection determines what mutations are accepted, but its importance for shaping the resulting networks has been debated.

Publiceringsår

2016

Språk

Engelska

Publikation/Tidskrift/Serie

PLoS ONE

Volym

11

Issue

2

Dokumenttyp

Artikel i tidskrift

Förlag

Public Library of Science (PLoS)

Ämne

  • Bioinformatics and Systems Biology
  • Other Physics Topics
  • Genetics

Status

Published

ISBN/ISSN/Övrigt

  • ISSN: 1932-6203