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Vascular Endothelial Growth Factor in Central Nervous System Injuries - A Vascular Growth Factor Getting Nervous?

In English

Författare

  • Mattias Skold
  • Martin Kanje

Summary, in English

Vascular Endothelial Growth Factor ( VEGF) is recognized as a central factor in growth, survival and permeability of blood vessels in both physiological and pathological conditions. It is as such of importance for vascular responses in various central nervous system (CNS) disorders. Accumulating evidence suggest that VEGF may also act as a neuroprotective and neurotrophic factor supporting neuronal survival and neuronal regeneration. Findings of neuropilins as shared co-receptors between molecules with such seemingly different functions as the axon guidance molecules semaphorins and VEGF has further boosted the interest in the role of VEGF in neural tissue injury and repair mechanisms. Thus, VEGF most likely act in parallel or concurrent on cells in both the vascular and nervous system. The present review gives a summary of known or potential aspects of the VEGF system in the healthy and diseased nervous system. The potential benefits but also problems and pitfalls in intervening in the actions of such a multifunctional factor as VEGF in the disordered CNS are also covered.

Publiceringsår

2008

Språk

Engelska

Sidor

246-259

Publikation/Tidskrift/Serie

Current Neurovascular Research

Volym

5

Issue

4

Dokumenttyp

Artikel i tidskrift

Förlag

Bentham Science Publishers

Ämne

  • Zoology

Status

Published

ISBN/ISSN/Övrigt

  • ISSN: 1567-2026