Cytogenetic abnormalities and clonal evolution in an adult hepatoblastoma
Författare
Summary, in English
Hepatoblastomas usually occur in children < 3 years of age, and only occasional adult cases have been described. To date, 20 cytogenetically abnormal childhood hepatoblastomas have been reported. Karyotypic investigations have shown that most hepatoblastomas are diploid or hyperdiploid, often displaying trisomies for chromosomes 2 and 20. We have cytogenetically investigated an adult hepatoblastoma for which no previous karyotypic data exist. A hypertriploid stemline with multiple numerical and structural chromosomal aberrations, including +2 and +20, was found. In addition, the tumor displayed extensive clonal evolution with 11 subclones. Although the tumor thus displayed some chromosomal abnormalities commonly observed in childhood tumors, providing further support for the importance of these abnormalities in the development of hepatoblastoma, the level of genomic complexity seen in the present case has never been described in childhood hepatoblastomas and may suggest a different etiology or pathogenesis.
Avdelning/ar
Publiceringsår
1997
Språk
Engelska
Sidor
6-1381
Publikation/Tidskrift/Serie
American Journal of Surgical Pathology
Volym
21
Issue
11
Länkar
Dokumenttyp
Artikel i tidskrift
Förlag
Lippincott Williams & Wilkins
Ämne
- Medical and Health Sciences
Nyckelord
- Keratins/analysis
- Karyotyping
- Immunohistochemistry
- Humans
- Hepatoblastoma/chemistry/ genetics/ pathology
- Pair 1
- Human
- Chromosomes
- Chromosome Disorders
- Aged
- Chromosome Aberrations
- Liver Neoplasms/chemistry/ genetics/ pathology
- Male
- Tumor Markers
- Biological/analysis
Status
Published
ISBN/ISSN/Övrigt
- ISSN: 1532-0979