Circulating complexes between tumour necrosis factor-alpha and etanercept predict long-term efficacy of etanercept in juvenile idiopathic arthritis.

Summary, in English

The relationship between tumour necrosis factor-alpha (TNF-α) and drug survival had not been studied in juvenile idiopathic arthritis (JIA) and there were no laboratory tests to predict the long-term efficacy of biological drugs for JIA. We studied if serum levels of TNF-α, free or bound to etanercept, could predict long-term efficacy of etanercept in children with JIA.

• Författare: Robin Kahn; Elisabet Berthold; Birgitta Gullstrand; Tobias Schmidt; Fredrik Kahn; Pierre Geborek; Tore Saxne; Anders Bengtsson; Bengt Månsson
• Avdelning/ar: Pediatrik, Lund; Reumatologi och molekylär skelettbiologi; Avdelningen för mikrobiologi, immunologi och glykobiologi - MIG; Infektionsmedicin; EpiHealth: Epidemiology for Health
• Publiceringsår: 2016
• Språk: Engelska
• Sidor: 427-432
• Publikation/Tidskrift/Serie: Acta paediatrica
• Volym: 105
• Issue: 4
• Länkar: http://www.ncbi.nlm.nih.gov/pubmed/26707699?dopt=Abstract; http://dx.doi.org/10.1111/apa.13319
• Dokumenttyp: Artikel i tidskrift
• Förlag: Wiley-Blackwell
• Ämne: Rheumatology and Autoimmunity; Pediatrics
• Status: Published
• ISBN/ISSN/Övrigt: ISSN: 1651-2227