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Activation of a Temporal Memory in Purkinje Cells by the mGluR7 Receptor.

In English

Författare

Summary, in English

Cerebellar Purkinje cells can learn to respond to a conditioned stimulus with an adaptively timed pause in firing. This response was usually ascribed to long-term depression of parallel fiber to Purkinje cell synapses but has recently been shown to be due to a previously unknown form of learning involving an intrinsic cellular timing mechanism. Here, we investigate how these responses are elicited. They are resistant to blockade of GABAergic inhibition, suggesting that they are caused by glutamate release rather than by a changed balance between GABA and glutamate. We show that the responses are abolished by antagonists of the mGlu7 receptor but not significantly affected by other glutamate antagonists. These results support the existence of a distinct learning mechanism, different from changes in synaptic strength. They also demonstrate in vivo post-synaptic inhibition mediated by glutamate and show that the mGlu7 receptor is involved in activating intrinsic temporal memory.

Publiceringsår

2015

Språk

Engelska

Sidor

1741-1746

Publikation/Tidskrift/Serie

Cell Reports

Volym

13

Issue

9

Dokumenttyp

Artikel i tidskrift

Förlag

Cell Press

Ämne

  • Neurosciences

Status

Published

Projekt

  • Thinking in Time: Cognition, Communication and Learning

Forskningsgrupp

  • Associative Learning

ISBN/ISSN/Övrigt

  • ISSN: 2211-1247