Heritability of variation in glycaemic response to metformin: a genome-wide complex trait analysis.

Summary, in English

Metformin is a first-line oral agent used in the treatment of type 2 diabetes, but glycaemic response to this drug is highly variable. Understanding the genetic contribution to metformin response might increase the possibility of personalising metformin treatment. We aimed to establish the heritability of glycaemic response to metformin using the genome-wide complex trait analysis (GCTA) method.

• Författare: Kaixin Zhou; Louise Donnelly; Jian Yang; Miaoxin Li; Harshal Deshmukh; Natalie Van Zuydam; Emma Ahlqvist; Chris C Spencer; Leif Groop; Andrew D Morris; Helen M Colhoun; Pak C Sham; Mark I McCarthy; Colin N A Palmer; Ewan R Pearson
• Avdelning/ar: Translationell Muskel Forskning; EXODIAB: Excellence of Diabetes Research in Sweden
• Publiceringsår: 2014
• Språk: Engelska
• Sidor: 481-487
• Publikation/Tidskrift/Serie: The Lancet Diabetes & Endocrinology
• Volym: 2
• Issue: 6
• Länkar: http://www.ncbi.nlm.nih.gov/pubmed/24731673?dopt=Abstract; http://dx.doi.org/10.1016/S2213-8587(14)70050-6
• Dokumenttyp: Artikel i tidskrift
• Förlag: Elsevier
• Ämne: Endocrinology and Diabetes
• Status: Published
• Forskningsgrupp: Genomics, Diabetes and Endocrinology
• ISBN/ISSN/Övrigt: ISSN: 2213-8595