High levels of cathepsin D and cystatin B are associated with increased risk of coronary events.

Summary, in English

The majority of acute coronary syndromes are caused by plaque ruptures. Proteases secreted by macrophages play an important role in plaque ruptures by degrading extracellular matrix proteins in the fibrous cap. Matrix metalloproteinases have been shown to be markers for cardiovascular disease whereas the members of the cathepsin protease family are less studied.

• Författare: Isabel Goncalves; Karin Hultman; Pontus Dunér; Andreas Edsfeldt; Bo Hedblad; Gunilla Nordin Fredrikson; Harry Björkbacka; Jan Nilsson; Eva Bengtsson
• Avdelning/ar: EXODIAB: Excellence of Diabetes Research in Sweden; EpiHealth: Epidemiology for Health; Kardiovaskulär forskning - translationella studier; Kardiovaskulär forskning - immunitet och ateroskleros; Kardiovaskulär forskning - epidemiologi
• Publiceringsår: 2016
• Språk: Engelska
• Sidor: 000353-000353
• Publikation/Tidskrift/Serie: Open Heart
• Volym: 3
• Issue: 1
• Länkar: http://www.ncbi.nlm.nih.gov/pubmed/26848396?dopt=Abstract; http://dx.doi.org/10.1136/openhrt-2015-000353
• Dokumenttyp: Artikel i tidskrift
• Förlag: BMJ Publishing Group
• Ämne: Cardiac and Cardiovascular Systems
• Status: Published
• Forskningsgrupp: Cardiovascular Research - Translational Studies; Cardiovascular Research - Immunity and Atherosclerosis; Cardiovascular Research - Epidemiology
• ISBN/ISSN/Övrigt: ISSN: 2053-3624