Webbläsaren som du använder stöds inte av denna webbplats. Alla versioner av Internet Explorer stöds inte längre, av oss eller Microsoft (läs mer här: * https://www.microsoft.com/en-us/microsoft-365/windows/end-of-ie-support).

Var god och använd en modern webbläsare för att ta del av denna webbplats, som t.ex. nyaste versioner av Edge, Chrome, Firefox eller Safari osv.

Heritability of model-derived parameters of beta cell secretion during intravenous and oral glucose tolerance tests: a study of twins

In English

Författare

  • M Lehtovirta
  • J Kaprio
  • Leif Groop
  • M Trombetta
  • RC Bonadonna

Summary, in English

Aims/hypothesis: The genetic architecture of model- derived parameters of beta cell function has never been assessed. Therefore, we estimated heritability (h(2)) for model- derived phenotypes of insulin secretion in twins. Methods: Thirty-three monozygotic (MZ) and 23 dizygotic (DZ) twin pairs from the Finnish Twin Cohort Study underwent OGTT (plasma glucose/C-peptide at 0, 30, 60, 90 and 120 min). A subset of the twin pairs (21 MZ/ 20 DZ) also underwent an IVGTT ( frequent sampling of plasma glucose/ insulin from 0 to 60 min) followed by a 160-min euglycaemic-hyperinsulinaemic clamp (45 mU . min(-1) . m(-2)). Mathematical modelling was applied to the IVGTT and the OGTT to assess first-phase ( readily releasable insulin [RRI]) and second- phase ( sigma) secretion ( IVGTT), and a global index of beta cell performance ( OGTT beta index). Intraclass correlation coefficients and genetic and non-genetic components for trait variances were computed to assess the h(2) of model- derived parameters. Results: The intraclass correlation coefficients in MZ twins were 0.78 for RRI, 0.67 for sigma and 0.57 for OGTT beta index. In DZ twins the correlation coefficients were 0.23, 0.32 and 0.42, respectively. Using the most parsimonious model for each trait, the h(2) - the proportion of variance accounted for by genetic factors - was 76% ( 95% CI: 53 - 88%) for RRI, 28% ( 34 - 80%) for sigma and 53% ( 26 - 72%) for OGTT beta index. Conclusions/ interpretation: Our findings demonstrate that model- derived parameters of insulin secretion have a substantial genetic component and may be used in the search for genetic determinants of beta cell function in humans.

Publiceringsår

2005

Språk

Engelska

Sidor

1604-1613

Publikation/Tidskrift/Serie

Diabetologia

Volym

48

Issue

8

Dokumenttyp

Artikel i tidskrift

Förlag

Springer

Ämne

  • Endocrinology and Diabetes

Nyckelord

  • beta cell
  • C-peptide
  • heritability
  • insulin
  • twins
  • model

Status

Published

Forskningsgrupp

  • Genomics, Diabetes and Endocrinology

ISBN/ISSN/Övrigt

  • ISSN: 1432-0428