Radiation treatment monitoring using multimodal functional imaging: PET/CT ((18)F-Fluoromisonidazole & (18)F-Fluorocholine) and DCE-US.

Summary, in English

This study aims to assess the effect of radiation treatment on the tumour vasculature and its downstream effects on hypoxia and choline metabolism using a multimodal approach in the murine prostate tumour model CWR22. Functional parameters derived from Positron Emission Tomography (PET)/Computer Tomography (CT) with (18)F-Fluoromisonidazole ((18)F-FMISO) and (18)F-Fluorocholine ((18)F-FCH) as well as Dynamic Contrast-Enhanced Ultrasound (DCE-US) were employed to determine the relationship between metabolic parameters and microvascular parameters that reflect the tumour microenvironment. Immunohistochemical analysis was employed for validation.

• Författare: Natalia Arteaga-Marrero; Cecilie Brekke Rygh; Jose F Mainou-Gomez; Tom C H Adamsen; Nataliya Lutay; Rolf K Reed; Dag R Olsen
• Avdelning/ar: Dermatologi och venereologi, Lund; Avdelningen för medicinsk mikrobiologi; Avdelningen för mikrobiologi, immunologi och glykobiologi - MIG
• Publiceringsår: 2015
• Språk: Engelska
• Publikation/Tidskrift/Serie: Journal of Translational Medicine
• Volym: 13
• Länkar: http://dx.doi.org/10.1186/s12967-015-0708-5
• Dokumenttyp: Artikel i tidskrift
• Förlag: BioMed Central (BMC)
• Ämne: Cancer and Oncology
• Status: Published
• ISBN/ISSN/Övrigt: ISSN: 1479-5876