Immunomodulation of atherosclerosis with a vaccine
Författare
Summary, in English
Experimental observations have established that the innate and adaptive immune mechanisms both have roles in the modulation of atherosclerosis. The complex function that the immune system has in the pathophysiology of atherosclerosis is highlighted by the fact that both proatherogenic and atheroprotective effects of immune activation can be demonstrated. An immune response to the protein and lipid components of oxidized LDL cholesterol has been observed in experimental models, and immunization with these antigens has generally reduced atherosclerosis. The findings suggest the tantalizing possibility that an atheroprotective vaccine can be developed. Our laboratories have identified several antigenic epitopes in the human apolipoprotein B 100 component of LDL cholesterol. Active immunization with some of these epitopes has reduced atherosclerosis in hyperlipidemic mice. We believe, therefore, that a vaccine based on apolipoprotein B100-related peptide could have a role in reducing atherosclerosis. In this review, we discuss the possible immunologic mechanisms by Which vaccines against atherosclerosis might work and the ways in which such treatment might be most effectively administered.
Publiceringsår
2005
Språk
Engelska
Sidor
639-646
Publikation/Tidskrift/Serie
Nature Clinical Practice Cardiovascular Medicine
Volym
2
Issue
12
Dokumenttyp
Artikel i tidskrift
Förlag
Nature Publishing Group
Ämne
- Cardiac and Cardiovascular Systems
Nyckelord
- atheroprotective
- atherosclerosis
- immune response
- vaccination
- proatherogenic
Status
Published
Forskningsgrupp
- Cardiovascular Research - Immunity and Atherosclerosis
ISBN/ISSN/Övrigt
- ISSN: 1743-4300