Thylakoids Promote Satiety in Healthy Humans. Metabolic Effects and Mechanisms
Författare
Summary, in English
Thylakoids are the photosynthetic membranes of the chloroplasts in green leaves. Thylakoids have been found to promote satiety when added to food, both in animal experimental models and in human. The thylakoids act through inhibition of lipase-colipase catalysed hydrolysis of triacylglycerol, which is the main dietary fat component. The mechanism for inhibition is either a binding of thylakoids to lipase-colipase, which thereby prevents to act as a lipolytic enzyme complex or binding of thylakoids to the triacylglycerol droplet, thereby hindering the access of lipase-colipase to its substrate. Thylakoids consist of proteins and lipids in a membrane structure containing various protein-bound pigments. The thylakoid membranes are fairly resistant to gastrointestinal breakdown, which may be an important property to explain the satiety promoting effect. Satiety is promoted through the release of cholecystokinin, a gastrointestinal hormone that causes an inhibition of gastric emptying and stimulation of satiety mechanism in the brain. The hunger hormone ghrelin is suppressed as well as insulin. In human short-term experiments thylakoids added to food promote satiety signalling. In long-term a reduced body fat mass was observed.
Publiceringsår
2012
Språk
Engelska
Sidor
521-531
Publikation/Tidskrift/Serie
ACS Symposium Series
Volym
1093
Dokumenttyp
Konferensbidrag
Förlag
The American Chemical Society (ACS)
Ämne
- Nutrition and Dietetics
- Other Clinical Medicine
Nyckelord
- Food intake
- insulin
- ghrelin
- leptin
- abdominal fat
- body fat
- CCK
- blood lipids
- blood glucose
Conference name
Symposium on Agricultural and Food Derived Natural Products for Preventing and Combating Disease
Conference date
2010-08-22 - 2010-08-26
Status
Published
Forskningsgrupp
- Appetite Regulation
ISBN/ISSN/Övrigt
- ISSN: 0097-6156