Webbläsaren som du använder stöds inte av denna webbplats. Alla versioner av Internet Explorer stöds inte längre, av oss eller Microsoft (läs mer här: * https://www.microsoft.com/en-us/microsoft-365/windows/end-of-ie-support).

Var god och använd en modern webbläsare för att ta del av denna webbplats, som t.ex. nyaste versioner av Edge, Chrome, Firefox eller Safari osv.

Differential regulation of alpha and beta chains of C4b-binding protein during acute-phase response resulting in stable plasma levels of free anticoagulant protein S

In English

Författare

Summary, in English

Regulation of C4b-binding protein (C4BP) isoforms during acute phase and its relationship to the plasma concentration of free protein S was elucidated. An assay for beta chain containing C4BP (C4BP beta+) was developed and the concentrations of total C4BP, C4BP beta+, total, free, and bound protein S were measured in patients with acute-phase response. Even though total C4BP was increased to 162% (mean value) of controls, the corresponding value of C4BP beta+ was only 122%. In the acute-phase group, total protein S was increased to the same extent as C4BP beta+ (mean value of 124%), whereas free protein S was not decreased. In controls, total and bound protein S correlated with total C4BP and C4BP beta+. However, in the acute-phase group, the correlation between bound protein S and total C4BP was lost, although the correlation between C4BP beta+ and protein S remained. The present results suggest stable levels of free protein S during acute phase to be the result of differential regulation of C4BP alpha- and beta-chain expression, and the concentration of free protein S to be the resulting molar excess of protein S over C4BP beta+. This mechanism ensures functional levels of free anticoagulant protein S despite high levels of C4BP.

Publiceringsår

1994

Språk

Engelska

Sidor

815-822

Publikation/Tidskrift/Serie

Blood

Volym

84

Issue

3

Dokumenttyp

Artikel i tidskrift

Förlag

American Society of Hematology

Ämne

  • Medicinal Chemistry

Nyckelord

  • Acute-Phase Proteins
  • Acute-Phase Reaction
  • Antibodies, Monoclonal
  • Calcium
  • Carrier Proteins
  • Complement C4b
  • Complement Inactivator Proteins
  • Glycoproteins
  • Humans
  • Macromolecular Substances
  • Protein S
  • Journal Article
  • Research Support, Non-U.S. Gov't

Status

Published

Forskningsgrupp

  • Clinical Chemistry, Malmö
  • Family Medicine and Clinical Epidemiology

ISBN/ISSN/Övrigt

  • ISSN: 1528-0020