Group A streptococci are protected from amoxicillin-mediated killing by vesicles containing β-lactamase derived from Haemophilus influenzae.

Summary, in English

Group A streptococci (GAS) cause, among other infections, pharyngotonsillitis in children. The species is frequently localized with the Gram-negative respiratory pathogens non-typeable Haemophilus influenzae (NTHi) and Moraxella catarrhalis, which both produce outer membrane vesicles (OMVs). The aim of this study was to investigate whether OMVs isolated from NTHi contain functional β-lactamase and whether the OMVs hydrolyse amoxicillin and thus protect GAS from killing by the antibiotic.

• Författare: Viveka Schaar; Ida Uddbäck; Therése Nordström; Kristian Riesbeck
• Avdelning/ar: Klinisk mikrobiologi, Malmö
• Publiceringsår: 2014
• Språk: Engelska
• Sidor: 117-120
• Publikation/Tidskrift/Serie: Journal of Antimicrobial Chemotherapy
• Volym: 69
• Issue: 1
• Fulltext: - 528 kB; Download statistics
• Länkar: http://www.ncbi.nlm.nih.gov/pubmed/23912886?dopt=Abstract; http://dx.doi.org/10.1093/jac/dkt307
• Dokumenttyp: Artikel i tidskrift
• Förlag: Oxford University Press
• Ämne: Pharmacology and Toxicology
• Status: Published
• Forskningsgrupp: Clinical Microbiology, Malmö
• ISBN/ISSN/Övrigt: ISSN: 1460-2091