Low-grade inflammation, oxidative stress and risk of invasive post-menopausal breast cancer - A nested case-control study from the Malmö diet and cancer cohort

Summary, in English

Objective: Although cancer promotes inflammation, the role of inflammation in tumor-genesis is less well established. The aim was to examine if low-grade inflammation is related to post-menopausal breast cancer risk, and if obesity modifies this association. Methods; In the Malmo Diet and Cancer cohort, a nested case-control study was defined among 8,513 women free of cancer and aged 55.73 years at baseline (1991.96); 459 were diagnosed with invasive breast cancer during follow-up (until December 31^st, 2010). In laboratory analyses of blood from 446 cases, and 885 controls (matched on age and date of blood sampling) we examined systemic inflammation markers: oxidized (ox)-LDL, interleukin (IL)- 1β, IL-6, IL-8, tumor necrosis factor (TNF)-α, white blood cells, lymphocytes and neutrophils. Odds ratios (OR) and 95% confidence intervals (CI) for breast cancer risk was calculated using multivariable conditional logistic regression. Results: Inverse associations with breast cancer were seen in fully-adjusted models, for 2^nd and 3^rd tertiles of ox-LDL, OR (95% CI): 0.65 (0.47.0.90), 0.63 (0.45.0.89) respectively, p-trend = 0.01; and for the 3^rd tertile of TNF-α, 0.65 (0.43.0.99), p-trend = 0.04. In contrast, those in the highest IL-1β category had higher risk, 1.71 (1.05.2.79), p-trend = 0.01. Obesity did not modify associations between inflammation biomarkers and breast cancer. Conclusion; Our study does not suggest that low-grade inflammation increase the risk of post-menopausal breast cancer.

• Författare: Joana Alves Dias; Gunilla Nordin Fredrikson; Ulrika Ericson; Bo Gullberg; Bo Hedblad; Gunnar Engström; Signe Borgquist; Jan Nilsson; Elisabet Wirfält
• Avdelning/ar: EXODIAB: Excellence of Diabetes Research in Sweden; EpiHealth: Epidemiology for Health; Nutritionsepidemiologi; Kardiovaskulär forskning - immunitet och ateroskleros; Diabetes - kardiovaskulär sjukdom; Kardiovaskulär forskning - epidemiologi; BioCARE: Biomarkers in Cancer Medicine improving Health Care, Education and Innovation; Bröstcancer-genetik
• Publiceringsår: 2016-07-01
• Språk: Engelska
• Publikation/Tidskrift/Serie: PLoS ONE
• Volym: 11
• Issue: 7
• Länkar: http://dx.doi.org/10.1371/journal.pone.0158959
• Dokumenttyp: Artikel i tidskrift
• Förlag: Public Library of Science (PLoS)
• Ämne: Cancer and Oncology; Public Health, Global Health, Social Medicine and Epidemiology
• Status: Published
• Forskningsgrupp: Nutrition Epidemiology; Cardiovascular Research - Immunity and Atherosclerosis; Diabetes - Cardiovascular Disease; Cardiovascular Research - Epidemiology
• ISBN/ISSN/Övrigt: ISSN: 1932-6203