Synthesis and biological evaluation of paclitaxel-thiocoichicine hybrids
Författare
Summary, in English
The bifunctional taxoid-colchicinoid hybrids 6-8 were synthesized and evaluated in assays of cytotoxicity and tubulin assembly/disassembly. All compounds showed a high degree of cytotoxicity, but, while 6 and 7 behaved as bifunctional tubulin binders not unlike an equimolecular mixture of taxol and thiocolchicine, 8 was surprisingly devoid of tubulin activity, acting on a distinct and yet to identify molecular target.
Avdelning/ar
Publiceringsår
2004
Språk
Engelska
Sidor
327-345
Publikation/Tidskrift/Serie
Chemistry and Biodiversity
Volym
1
Issue
2
Dokumenttyp
Artikel i tidskrift
Förlag
Verlag Helvetica Chimica Acta
Ämne
- Organic Chemistry
Status
Published
ISBN/ISSN/Övrigt
- ISSN: 1612-1872