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Surface proteins of the Group G Streptococcus in different phases of growth: patterns of production and implications for the host-bacteria relationship.

Författare

Summary, in English

Group G streptococcus (GGS) is a human bacterial pathogen expressing surface proteins FOG and protein G (PG) which interact with several host defense systems, including the complement and contact systems. Selected reaction monitoring mass spectrometry, electron microscopy, and protein binding assays were used to follow the amounts of FOG and PG intracellularly and on the bacterial surface during different phases of growth. Large and increasing amounts of PG were present on the surface in the stationary growth phase, and this was due to de novo production. In contrast, the amount of FOG did not change substantially during this phase. Apart from PG, a number of housekeeping proteins also increased in abundance in the stationary phase. These results show that GGS protein production is active during the stationary phase and that the bacteria actively remodel their surface and enter a less pro-inflammatory state in this phase.

Publiceringsår

2014

Språk

Engelska

Sidor

279-286

Publikation/Tidskrift/Serie

Microbiology

Volym

160

Issue

Nov 12

Dokumenttyp

Artikel i tidskrift

Förlag

MAIK Nauka/Interperiodica

Ämne

  • Infectious Medicine

Status

Published

Forskningsgrupp

  • Infection Medicine Proteomics

ISBN/ISSN/Övrigt

  • ISSN: 1465-2080