Rat tooth pulp cells elicit neurite growth from trigeminal neurones and express mRNAs for neurotrophic factors in vitro
Författare
Summary, in English
Molecular factors control the developmental ingrowth of axons to the tooth pulp. Here we examine the ability of pulpal cells to induce neurite outgrowth from neonatal rat trigeminal neurones (TGNs) in vitro. We found that TGNs emitted neurites and formed networks of branches in relation to pulpal cells. Neurones co-cultured with a mixture of pulpal cells and 3T3 fibroblasts formed networks exclusively in relation to the pulpal cells. Cultivated pulpal cells and pulpal tissue produced mRNAs for all neurotrophins and members of the glial cell line-derived neurotrophic factor family. Hence, rat pulpal cells have neuritogenic effects on single TGNs in vitro, that may be associated with secretion of neurotrophic factors.
Avdelning/ar
Publiceringsår
2001
Språk
Engelska
Sidor
161-164
Publikation/Tidskrift/Serie
Neuroscience Letters
Volym
308
Issue
3
Länkar
Dokumenttyp
Artikel i tidskrift
Förlag
Elsevier
Ämne
- Neurosciences
Nyckelord
- Trigeminal ganglion
- Dental pulp
- Rat
- Cell culture
- Neurotrophic factors
- Neuritogenesis
Status
Published
Forskningsgrupp
- Neurophysiology
- Neuronano Research Center (NRC)
ISBN/ISSN/Övrigt
- ISSN: 0304-3940