Synthesis of aromatic C-xylosides by position inversion of glucose

Summary, in English

Two formally C-xylosylated analogs to 2-naphthyl beta-D-xylopyranoside, which is known to initiate priming of glucosaminoglycan chains, were synthesized by a position inversion of glucose (i.e., position I becomes position 5). The D-C-xyloside showed priming, while the L-C-xyloside did not initiate priming. (c) 2006 Elsevier Ltd. All rights reserved.

• Författare: Jesper Malmberg; Katrin Mani; Elin Säwén; Anders Wiren; Ulf Ellervik
• Avdelning/ar: Centrum för analys och syntes; Glykobiologigruppen
• Publiceringsår: 2006
• Språk: Engelska
• Sidor: 6659-6665
• Publikation/Tidskrift/Serie: Bioorganic & Medicinal Chemistry
• Volym: 14
• Issue: 19
• Länkar: http://dx.doi.org/10.1016/j.bmc.2006.05.068
• Dokumenttyp: Artikel i tidskrift
• Förlag: Elsevier
• Ämne: Medicinal Chemistry
• Nyckelord: structure-activity relationships; C-glycosides; carbohydrates; xylose
• Status: Published
• Forskningsgrupp: Glycobiology
• ISBN/ISSN/Övrigt: ISSN: 0968-0896